Total de pilots participants: 93 (33 a Indianapolis)
Total d’equips participants: 61 (27 a Indianapolis)
Debutants: 26 (Roberto Bonomi, Oscar Cabalén, Ettore Chimeri, Jim Clark. Antonio Creus, Chuck Daigh, Bob Drake, Piero Drogo, Nasif Estéfano, Fred Gamble, Richie Ginther, Jim Hall, Jim Hurtubise, Alberto Rodríguez Larreta, Pedro Llano, Willy Mairesse, Gino Munaron, Arthur Owen, Julio Pola, Lance Reventlow, Lloyd Ruby, John Surtees, Alfonso Thiele, Bud Tingelstad, Wayne Weiler, Vic Wilson)
Última temporada: 57 (Red Amick, Tony Bettenhausen, Roberto Bonomi, Johnny Boyd, Don Branson, Chris Bristow, Jimmy Bryan, Oscar Cabalén, Giulio Cabianca, Duane Carter, Ettore Chimeri, Bob Christie, Antonio Creus, Chuck Daigh, Bob Drake, Piero Drogo, Ron Flockhart, Gene Force, A.J. Foyt, Don Freeland, Fred Gamble, Paul Goldsmith, José Froilán González, Horace Gould, Bobby Grim, Bruce Halford, Gene Hartley, Al Herman, Bill Homeier, Jim Hurtubise, Eddie Johnson, Alberto Rodríguez Larreta, Pedro Llano, Jim McWithey, Carlos Menditéguy, Gino Munaron, Arthur Owen, David Piper, Julio Pola, Dick Rathmann, Jim Rathmann, Lance Reventlow, Eddie Russo, Troy Ruttman, Eddie Sachs, Harry Schell, Alan Stacey, Chuck Stevenson, Len Sutton, Mike Taylor, Shorty Templeman, Alfonso Thielem Johnny Thomson, Bud Tingelstad, Bob Veith, Wayne Weiler, Dempsey Wilson)
Defuncions a la F1: 2 (Chris Bristow, Alan Stacey)
Defuncions en altres categories: 5 (Jimmy Bryan, Ettore Chimeri, Al Herman, Harry Schell, Johnny Thomson)
Defuncions no relacionades amb l’esport: 0
Retirats per lesions a la F1: 1 (Mike Taylor)
Retirats per lesions a la F1: 1 (Mike Taylor)
Retirats per lesions en altres categories: 0
Pilot més jove: Bruce McLaren, 22 anys i 166 dies, Argentina
Pilot més vell: Jack Fairman, 47 anys i 135 dies, Gran Bretanya
| Entrant | Cotxe | Pneu. | Pilots |
| David Brown Corporation | Aston Martin DBR4 Aston Martin DBR5 |
D | Roy Salvadori Maurice Trintignant |
| Scuderia Ferrari | Ferrari 246 Ferrari 246P |
D | Cliff Allison Wolfgang von Trips Froilán González Phil Hill Richie Ginther Willy Mairesse |
| Cooper Car Company | Cooper T51-Climax Cooper T53-Climax |
D | Jack Brabham Bruce McLaren Chuck Daigh Lance Reventlow Ron Flockhart |
| Scuderia Centro Sud | Cooper T51-Maserati | D | Wolfgang von Trips Maurice Trintignant Masten Gregory Alfonso Thiele Ian Burgess Nicha Cabral Roberto Bonomi Carlos Menditéguy |
| Team Lotus | Lotus 16-Climax Lotus 18-Climax |
D | Innes Ireland Alan Stacey Jim Clark John Surtees Ron Flockhart Alberto R. Larreta |
| Vandervell Products | Vanwall VW11 | D | Tony Brooks |
| Owen Racing Organisation | BRM P25 BRM P48 |
D | Graham Hill Jo Bonnier Dan Gurney |
| R. R. C. Walker Racing Team |
Cooper T51-Climax Lotus 18-Climax |
D | Stirling Moss Maurice Trintignant |
| Dr. Ing. F. Porsche KG Porsche System Engineering |
Porsche 718/2 | D | Edgar Barth Hans Herrmann |
| Ecurie Maarsbergen | Cooper T51-Climax | D | Carel Godin de Beaufort |
| J. B. Naylor | JBW 59-Maserati | D | Brian Naylor |
| Reventlow Automobiles Inc. | Scarab F1 | D | Lance Reventlow Chuck Daigh Richie Ginther |
| Scuderia Eugenio Castellotti | Cooper T51-Castellotti | D | Gino Munaron Giorgio Scarlatti Giulio Cabianca |
| H. H. Gould | Maserati 250F | D | Horace Gould |
| Giorgio Scarlatti | Maserati 250F | D | Giorgio Scarlatti |
| Gino Munaron | Maserati 250F | D | Gino Munaron |
| Antonio Creus | Maserati 250F | D | Antonio Creus |
| Nasif Estéfano | Maserati 250F | D | Nasif Estéfano |
| Joe Lubin | Maserati 250F | D | Bob Drake |
| Camoradi International | Behra-Porsche RSK | D | Masten Gregory Fred Gamble |
| Yeoman Credit Racing Team |
Cooper T51-Climax | D | Tony Brooks Chris Bristow Henry Taylor Bruce Halford Olivier Gendebien Phil Hill |
| High Efficiency Motors C. T. Atkins |
Cooper T51-Climax | D | Roy Salvadori Jack Fairman |
| Equipe Nationale Belge | Cooper T45-Climax | D | Lucien Bianchi |
| Fred Tuck Cars | Cooper T51-Climax | D | Bruce Halford Lucien Bianchi |
| Robert Bodle Ltd. | Lotus 16-Climax | D | David Piper |
| Jim Hall | Lotus 18-Climax | D | Jim Hall |
| Arthur Owen | Cooper T45-Climax | D | Arthur Owen |
| Wolfgang Seidel | Cooper T45-Climax | D | Wolfgang Seidel |
| Gilby Engineering | Cooper T45-Maserati | D | Keith Greene |
| Scuderia Colonia | Cooper T43-Climax | D | Piero Drogo |
| Taylor-Crawley Racing Team |
Lotus 18-Climax | D | Mike Taylor |
| Equipe Prideaux/ Dick Gibson |
Cooper T43-Climax | D | Vic Wilson |
| Equipe Bleue | Cooper T51-Climax | D | Harry Schell |
| Fred Armbuster | Cooper T45-Ferrari | D | Pete Lovely |
| Leader Cards Inc. | Watson-Offy | F | Rodger Ward Chuck Stevenson |
| Ken-Paul Inc. | Watson-Offy | F | Jim Rathmann |
| Bignotti-Bowes Racing | Epperly-Offy Kurtis Kraft-Offy |
F | Johnny Boyd A. J. Foyt |
| Peter Salemi & Nick Rini | Watson-Offy | F | Len Sutton |
| William P. Forbes | Meskowski-Offy | F | Bobby Grim |
| Ernest L. Ruiz | Christensen-Offy | F | Jim Hurtubise |
| George Salih | Epperly-Offy | F | Jimmy Bryan |
| Hoover Motor Express Inc. | Epperly-Offy | F | Jim McWithey |
| J. Ensley & S. Murphy | Kuzma-Offy | F | Duane Carter |
| J. S. Donaldson | Kurtis Kraft 500G-Offy | F | Dempsey Wilson |
| Racing Associates | Lesovsky-Offy Kurtis Kraft-Offy |
F | Johnny Thomson Don Freeland |
| Leonard A. Faas | Salih-Offy | F | Red Amick |
| Ansted Rotary Co. | Epperly-Offy | F | Wayne Weiler |
| C. O. Prather | Kurtis Kraft 500G-Offy | F | Eddie Russo |
| Lindsey Hopkins | Watson-Offy | F | Tony Bettenhausen |
| Bob Estes | Phillips-Offy | F | Don Branson |
| Joe Hunt | Ewing-Offy | F | Al Herman |
| Chapman S. Root | Kurtis Kraft 500G-Offy | F | Gene Hartley |
| Norman Hall | Kuzma-Offy | F | Bill Homeier |
| Roy McKay | Kurtis Kraft 500G-Offy | F | Gene Force |
| Dean Van Lines | Kuzma-Offy | F | Eddie Sachs |
| Peter Schmidt | Meskowski-Offy | F | Bob Veith |
| John Zink | Watson-Offy | F | Troy Ruttman |
| J. C. Agajanian | Watson-Offy | F | Lloyd Ruby |
| Federal Auto Associates | Kurtis Kraft 500C-Offy | F | Bob Christie Shorty Templeman |
| Jim Robbins | Trevis-Offy Watson-Offy |
F | Bud Tinglestad Eddie Johnson Dick Rathmann |
| Norman C. Demler | Epperly-Offy | F | Paul Goldsmith |