Total de pilots participants: 88 (33 a Indianapolis)
Total d’equips participants: 58 (28 a Indianapolis)
Debutants: 27 (Cliff Allison, George Amick, Art Bisch, Tom Bridger, Ian Burgess, Giulio Cabianca, Maria Teresa de Filippis, Bernie Ecclestone, A.J. Foyt, Christian Goethals, Paul Goldsmith, André Guelfi, Graham Hill, Phil Hill, Ken Kavanagh, Bruce Kessler, Robert La Caze, Jud Larson, Bruce McLaren, François Picard, Carroll Shelby, Alan Stacey, Len Sutton, Luigi Taramazzo, André Testut, Jerry Unser, Dempsey Wilson)
Última temporada: 29 (George Amick, Art Bisch, Tom Bridger, Louis Chiron, Peter Collins, Bernie Ecclestone, Ed Elisian, Paul Emery, Juan Manuel Fangio, Billy Garrett, Gerino Gerini, Dick Gibson, Paco Godia, Christian Goethals, André Guelfi, Mike Hawthorn, Ken Kavanagh, Bruce Kessler, Robert La Caze, Stuart Lewis-Evans, Luigi Musso, Pat O’Connor, Johnnie Parsons, François Picard, Luigi Piotti, Jimmy Reece, Luigi Taramazzo, Johnnie Tolan, Jerry Unser)
Defuncions a la F1: 4 (Peter Collins, Stuart Lewis-Evans, Luigi Musso, Pat O’Connor)
Defuncions en altres categories: 2 (Art Bisch, Jimmy Reece)
Defuncions no relacionades amb l’esport: 0
Retirats per lesions a la F1: 1 (François Picard)
Retirats per lesions a la F1: 1 (François Picard)
Retirats per lesions en altres categories: 0
Pilot més jove: Bruce McLaren, 20 anys i 343 dies, Alemanya
Pilot més vell: Juan Manuel Fangio, 47 anys i 24 dies, França
| Entrant | Cotxe | Pneu. | Pilots |
| Scuderia Sud Americana | Maserati 250F | P | Juan Manuel Fangio Carlos Menditéguy |
| Scuderia Ferrari | Ferrari 246 Ferrari 156 |
E | Luigi Musso Peter Collins Mike Hawthorn Wolfgang von Trips Phil Hill Olivier Gendebien |
| Cooper Car Company | Cooper T44-Climax Cooper T45-Climax |
D | Jack Brabham Bruce McLaren Ian Burgess Roy Salvadori Jack Fairman |
| Scuderia Centro Sud | Maserati 250F Cooper T43-Climax |
P D |
Gerino Gerini Maria Teresa de Filippis Carroll Shelby Troy Ruttman Masten Gregory Hans Herrmann Wolfgang Seidel Maurice Trintignant Jo Bonnier Cliff Allison |
| Team Lotus | Lotus 12-Climax Lotus 16-Climax |
D | Cliff Allison Graham Hill Alan Stacey |
| B. C. Ecclestone | Connaught B-Alta | A | Bernie Ecclestone Paul Emery Jack Fairman Ivor Bueb Bruce Kessler |
| Vandervell Products | Vanwall VW5 | D | Stirling Moss Tony Brooks Stuart Lewis-Evans |
| Owen Racing Organisation | BRM P25 | D | Ron Flockhart Maurice Trintignant Jean Behra Jo Bonnier Harry Schell |
| R. R. C. Walker Racing Team |
Cooper T43-Climax Cooper T45-Climax |
C D |
Stirling Moss Ron Flockhart Maurice Trintignant François Picard |
| Dr. Ing. F. Porsche KG | Porsche RSK | D | Edgar Barth |
| Ecurie Maarsbergen | Porsche RS550 Porsche RSK |
D | Carel Godin de Beaufort |
| Jo Bonnier | Maserati 250F | P | Jo Bonnier Harry Schell Phil Hill Giulio Cabianca Hans Herrmann |
| Ken Kavanagh | Maserati 250F | P | Ken Kavanagh Jean Behra Luigi Taramazzo |
| J. B. Naylor | Cooper T45-Climax | D | Brian Naylor |
| Dick Gibson | Cooper T43-Climax | D | Dick Gibson |
| Francesc Godia Sales | Maserati 250F | P | Paco Godia |
| M. T. de Filippis | Maserati 250F | P | Maria Teresa de Filippis |
| Giorgio Scarlatti | Maserati 250F | P | Giorgio Scarlatti Jo Bonnier |
| André Testut | Maserati 250F | P | André Testut Louis Chiron |
| Juan Manuel Fangio | Maserati 250F | P | Juan Manuel Fangio |
| Temple Buell | Maserati 250F | P | Carroll Shelby Masten Gregory |
| H. H. Gould | Maserati 250F | D | Horace Gould Masten Gregory |
| British Racing Partnership | Cooper T45-Climax | D | Tom Bridger |
| OSCA Automobili | OSCA F2 | P | Luigi Piotti Giulio Cabianca |
| High Efficiency Motors | Cooper T43-Climax | D | Ian Burgess |
| Ecurie Eperon d’Or | Cooper T43-Climax | D | Christian Goethals |
| Ecurie Demi Litre | Lotus 12-Climax | D | Ivor Bueb |
| Tony Marsh | Cooper T45-Climax | D | Tony Marsh |
| André Guelfi | Cooper T45-Climax | D | André Guelfi |
| Robert La Caze | Cooper T45-Climax | D | Robert La Caze |
| Robert M. Bowes II | Kurtis Kraft 500G-Offy | F | Johnny Boyd Bob Veith |
| Pat Clancy | Kurtis Kraft 500G2-Offy | F | Al Keller |
| Roger Wolcott | Lesovsky-Offy | F | Rodger Ward |
| Henry Yunik | Kurtis Kraft 500G-Offy | F | Paul Goldsmith |
| George Salih | Salih-Offy | F | Jimmy Bryan |
| Joseph Massaglia Jr. | Lesovsky-Offy | F | Jack Turner |
| Lysle Greenman | Kuzma-Offy | F | Johnnie Tolan |
| J. S. Donaldson | Kurtis Kraft 500G-Offy | F | Eddie Johnson |
| Racing Associates | Kurtis Kraft-Offy | F | Johnny Thomson |
| Fred Gerhardt | Kurtis Kraft-Offy | F | Johnnie Parsons |
| H. A. Chapman | Kurtis Kraft 500G-Offy | F | Billy Garrett |
| George Walther Jr. | Kurtis Kraft 500G-Offy | F | Mike Magill |
| Lindsey Hopkins | Epperly-Offy | F | Jim Rathmann |
| Bob Estes | Phillips-Offy | F | Don Freeland |
| Bob Sorenson | Kuzma-Offy | F | Dempsey Wilson |
| Chapman S. Root | Kurtis Kraft 500G-Offy | F | Pat O’Connor |
| Cars Inc. | Kurtis Kraft 500C-Offy | F | Tony Bettenhausen |
| Roy McKay | Kurtis Kraft 500G-Offy | F | Jerry Unser |
| Dean Van Lines | Kuzma-Offy | F | A. J. Foyt |
| Peter Schmidt | Kuzma-Offy | F | Eddie Sachs |
| John Zink Ellen McKinney Zink |
Watson-Offy | F | Ed Elisian Jud Larson Jimmy Reece |
| Novi Racing Co. | Kurtis Kraft-Novi | F | Bill Cheesebourg Paul Russo |
| Federal Auto Associates | Kurtis Kraft 500C-Offy | F | Bob Christie |
| H. H. Johnson | Kuzma-Offy | F | Art Bisch |
| Jim Robbins | Kurtis Kraft 500G-Offy | F | Len Sutton |
| Kalamazoo Sports Inc. | Kurtis Kraft 500D-Offy Watson-Offy |
F | Shorty Templeman Dick Rathmann |
| Harry Dunn | Dunn-Offy | F | Chuck Weyant |
| Norman C. Demler | Epperly-Offy | F | George Amick |