Total de pilots participants: 85 (34 a Indianapolis)
Total d’equips participants: 52 (30 a Indianapolis)
Debutants: 22 (Jo Bonnier, Tony Brooks, Colin Chapman, Bob Christie, Paul Emery, Billy Garrett, Olivier Gendebien, Gerino Gerini, Óscar González, Bruce Halford, Les Leston, André Milhoux, Luigi Piotti, Alfonso de Portago, Giorgio Scarlatti, Archie Scott-Brown, Piero Scotti, Desmond Titterington, Johnnie Tolan, Wolfgang von Trips, Jack Turner, Bob Veith)
Última temporada: 20 (Keith Andrews, Élie Bayol, Colin Chapman, Duke Dinsmore, Paul Frère, Óscar González, Toulo de Graffenried, Cliff Griffith, Chico Landi, Robert Manzon, André Milhoux, Nano da Silva Ramos, Louis Rosier, Archie Scott-Brown, Piero Scotti, Bob Sweikert, Piero Taruffi, Desmond Titterington, Alberto Uria, Luigi Villoresi)
Defuncions a la F1: 0
Defuncions en altres categories: 2 (Louis Rosier, Bob Sweikert)
Defuncions no relacionades amb l’esport: 0
Retirats per lesions a la F1: 0
Retirats per lesions a la F1: 0
Retirats per lesions en altres categories: 0
Pilot més jove: Billy Garrett, 23 anys i 42 dies, Indianapolis
Pilot més vell: Louis Rosier, 50 anys i 286 dies, Alemanya
| Entrant | Cotxe | Pneu. | Pilots |
| Officine Alfieri Maserati | Maserati 250F | P | Cesare Perdisa Umberto Maglioli Piero Taruffi Luigi Piotti Luigi Villoresi Gerino Gerini Carlos Menditéguy Froilán González Stirling Moss Jean Behra Jo Bonnier Paco Godia Chico Landi |
| Scuderia Ferrari | Ferrari 555 Ferrari D50 |
E P |
Eugenio Castellotti Luigi Musso Peter Collins Juan Manuel Fangio Paul Frére Olivier Gendebien André Pilette Alfonso de Portago Wolfgang von Trips |
| Automobiles Bugatti | Bugatti T251 | E | Maurice Trintignant |
| Scuderia Centro Sud | Maserati 250F Ferrari 500 |
P | Luigi Villoresi Giorgio Scarlatti Harry Schell Toulo de Graffenried |
| Giorgio Scarlatti | Ferrari 500 | P | Giorgio Scarlatti |
| Equipe Gordini | Gordini T16 Gordini T32 |
E | Élie Bayol Robert Manzon André Simon André Pilette André Milhoux Nano da Silva Ramos |
| Jack Brabham | Maserati 250F | D | Jack Brabham |
| Connaught Engineering | Connaught B-Alta | P A |
Archie Scott-Brown Desmond Titterington Jack Fairman Les Leston Ron Flockhart |
| Piero Scotti | Connaught B-Alta | P | Piero Scotti |
| Vandervell Products | Vanwall VW2 | P | Mike Hawthorn Colin Chapman Harry Schell Froilán González Maurice Trintignant Piero Taruffi |
| Owen Racing Organisation | Maserati 250F BRM P25 |
P D |
Mike Hawthorn Tony Brooks Ron Flockhart |
| Gould’s Garage | Maserati 250F | D | Horace Gould |
| Bob Gerard | Cooper T23-Bristol | D | Bob Gerard |
| Luigi Piotti | Maserati 250F | P | Luigi Piotti Luigi Villoresi |
| Emeryson Cars | Emeryson 56-Alta | D | Paul Emery |
| Alberto Uría | Maserati A6GCM | P | Alberto Uría Óscar González |
| Gilby Engineering | Maserati 250F | D | Roy Salvadori |
| Ecurie Rosier | Maserati 250F | P | Louis Rosier |
| Bruce Halford | Maserati 250F | D | Bruce Halford |
| Ottorino Volonterio | Maserati A6GCM | P | Ottorino Volonterio |
| André Simon | Maserati 250F | P | André Simon |
| Scuderia Guastalla | Maserati 250F | P | Umberto Maglioli Gerino Gerini |
| Fred Somers | Kurtis Kraft 500C-Offy | F | Ed Elisian Eddie Russo |
| Pat Clancy | Kurtis Kraft 500B-Offy | F | Al Herman |
| Carl L. Anderson | Kurtis Kraft 500C-Offy | F | Johnnie Tolan |
| George Bignotti | Kurtis Kraft 500E-Offy | F | Johnny Boyd |
| Federal Auto Associates | Kurtis Kraft 500C-Offy | F | Fred Agabashian Bob Veith |
| Joseph Massaglia Jr. | Lesovsky-Offy | F | Jimmy Reece |
| Jim Robbins | Stevens-Offy | F | Cliff Griffith |
| Murrell Belanger | Kurtis Kraft 500C-Offy | F | Tony Bettenhausen |
| Racing Associates | Kuzma-Offy | F | Bob Sweikert |
| Ed Walsh | Kurtis Kraft 500C-Offy | F | Rodger Ward |
| H. A. Chapman | Kurtis Kraft 500C-Offy | F | Andy Linden |
| E. R. Casale | Kuzma-Offy | F | Billy Garrett |
| Lindsey Hopkins | Kurtis Kraft 500C-Offy | F | Jim Rathmann |
| Bob Estes | Phillips-Offy | F | Don Freeland |
| Ansted Rotary Co. | Kurtis Kraft 500D-Offy | F | Pat O’Connor |
| Chapman S. Root | Kurtis Kraft 500D-Offy | F | Jimmy Daywalt |
| Cars Inc. | Kurtis Kraft 500C-Offy | F | Sam Hanks |
| Ray Crawford | Kurtis Kraft 500D-Offy | F | Ray Crawford |
| Dean Van Lines | Kuzma-Offy | F | Jimmy Bryan |
| Peter Schmidt | Kuzma-Offy | F | Johnny Thomson |
| John Zink | Watson-Offy Kurtis Kraft 500C-Offy |
F | Pat Flaherty Troy Ruttman |
| Novi Racing Co. | Kurtis Kraft-Novi | F | Paul Russo |
| Ernest L. Ruiz | Kurtis Kraft 500B-Offy | F | Jack Turner |
| H. H. Johnson | Kurtis Kraft 500D-Offy | F | Bob Christie |
| Shannon Bros. | Kurtis Kraft 500A-Offy | F | Duke Dinsmore |
| J. C. Agajanian | Kuzma-Offy | F | Johnnie Parsons |
| Samuel W. Traylor III | Kurtis Kraft 4000-Offy | F | Al Keller |
| Pete Salemi | Kuzma-Offy | F | Eddie Johnson Gene Hartley |
| Kalamazoo Sports Inc. | Kurtis Kraft 500C-Offy | F | Dick Rathmann |
| Harry Dunn | Kurtis Kraft 500B-Offy | F | Keith Andrews |